TPI1;TPI 1 CAS#: 79756-69-7

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TPI1;TPI 1

生物活性靶点体外研究体内研究 用途与合成方法 MSDS TPI1;TPI 1价格(试剂级) 上下游产品信息

中文名称	TPI1;TPI 1
中文同义词	TPI-1游离态;2',5'-二氯-[1,1'-联苯基]-2,5-二酮;化合物TPI1;2',5'-二氯-[1,1'-联苯基]-2,5-二酮
英文名称	2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
英文同义词	TPI-1;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;TPI1;TPI 1;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;Recombinant Human TIM/TPI1 Protein, His Tag;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;TPI-1,Inhibitor,inhibit,Phosphatase;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione
CAS号	79756-69-7
分子式	C12H6Cl2O2
分子量	253.08
EINECS号
相关类别
Mol文件	79756-69-7.mol
结构式

TPI1;TPI 1 性质

TPI1;TPI 1 用途与合成方法

生物活性

TPI-1 (Tyrosine Phosphatase Inhibitor 1)是一种有效的 SHP-1 抑制剂，对于重组SHP-1的IC50为40 nM。TPI-1具有抗癌的活性。

靶点

体外研究

SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ     ⁺    cells and induces IFNγ     ⁺    cells in human peripheral blood.

体内研究

TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ     ⁺    cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.

安全信息

MSDS信息

TPI1;TPI 1 价格(试剂级)

TPI1;TPI 1 上下游产品信息