1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 CAS#: 1163-36-6

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1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐价格(试剂级) 上下游产品信息

中文名称	1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
中文同义词	1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐;1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑 盐酸盐;克立咪唑盐酸;盐酸克立咪唑, >98%;盐酸克立咪唑;盐酸氯咪唑;克立咪唑盐酸盐;1-(4-氯苄基)-2-(吡咯烷-1-基甲基)-1H-苯并[D]咪唑盐酸盐
英文名称	Clemizole hydrochloride
英文同义词	1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride;1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole,hydrochloride;CS-1763;allercur;allercurehydrochloride;p48;1-P-CHLOROBENZYL-2-[1-PYRROLIDINYL]-METHYLBENZIMIDAZOLE HYDROCHLORIDE;1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride
CAS号	1163-36-6
分子式	C19H21Cl2N3
分子量	362.3
EINECS号	214-605-4
相关类别	抑制剂;小分子抑制剂;小分子抑制剂，天然产物;Inhibitors
Mol文件	1163-36-6.mol
结构式

1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 性质

1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 用途与合成方法

生物活性

Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂，抑制 HCV 复制。

靶点

IC50: 24 nM (NS4B)  
 H1 histamine receptor

体外研究

Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC     ₅₀    of Clemizole on the W55R mutant J6/JFH RNA is ~18 µM (2.25 times the EC     ₅₀    of the wild-type RNA). Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca     ²⁺    entry in the low micromolar range (IC     ₅₀    =1.0-1.3 µM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC     ₅₀    =6.4 µM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC     ₅₀    =9.1 µM) and TRPC6 (IC     ₅₀    =11.3 µM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 µM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC     ₅₀    of 1.1±0.04 µM.

体内研究

Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice.

用途 

用作氯咪唑青霉素等药物的中间体

安全信息

MSDS信息

1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 价格(试剂级)

1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 上下游产品信息

上游原料

邻氯硝基苯邻氯苯甲胺氯乙酰氯四氢吡咯氯化钠