去铁铵 CAS#: 138-14-7

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去铁铵

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 去铁铵价格(试剂级) 上下游产品信息 专题

中文名称	去铁铵
中文同义词	甲磺酸去铁胺;甲磺酸去铁敏;甲磺酸除铁灵;去铁铵/去铁敏;DEFEROX胺甲磺酸盐;去铁胺甲磺酸盐;去铁铵;去铁胺甲磺酸酯
英文名称	DEFEROXAMINE MESYLATE
英文同义词	deferoxaminebmesylate;deferoxaminemesilate;deferoxaminemethanesulfonate;desferal;desferalmesylate;desferalmethanesulfonate;desferrioxaminebmesylate;Deferoxamine Mesylate (300 mg)
CAS号	138-14-7
分子式	C26H52N6O11S
分子量	656.79
EINECS号	205-314-3
相关类别	医药中间体;小分子抑制剂;小分子抑制剂，天然产物;医药原料药-科研原料;医药原料;试剂盒-细胞分析试剂盒;标准品;Inhibitors;DESFERAL;Pharmaceuticals;Aliphatics;Amines;Chelating Agents & Ligands;Intermediates & Fine Chemicals
Mol文件	138-14-7.mol
结构式

去铁铵 性质

去铁铵 用途与合成方法

生物活性

Deferoxamine mesylate (Desferrioxamine B, DFOM)是Deferoxamine的甲磺酸盐，它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂，可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。

靶点

体外研究

Deferoxamine treatment significantly increases HIF-1α binding under all culture conditions, including hypoxic and high-glucose. The mechanism of deferoxamine is through improving HIF-1α biological function through scavenging oxygen free radicals. Deferoxamine (5 μM) has significant effect on the tumor-associated stromal cells cellular multiplication, and cells die at day 7 after exposure to 50 μM and 100 μM deferoxamine. Deferoxamine (5 μM-100 μM) inhibits the proliferation of BMMSCs, and induces apoptosis of MSCs in a dose-dependent manner. Deferoxamine influences the expression of adhesion proteins on MSCs. Deferoxamine (30, 60, 120 μM) shows lower expression of HIF-1α in a concentration dependent way in AdMSCs.

体内研究

Deferoxamine (100 mg/kg, i.p.) lowers the mortality rate of subarachnoid hemorrhage (SAH) rat. Deferoxamine (100 mg/kg, i.p.) attenuates Evan’s blue extravasation in cortex, ameliorates the tight junction detachment and preserves the integrity of the base membrane examined in electron microscope at day 3 after SAH. Deferoxamine attenuates degradation of BBB proteins after SAH and significantly reduces ferritin expression at day 3 in the cortex, and improves neurologic behavior and cognitive deficits after experimental. Ten µL of 1 mM deferoxamine-treated wounds display significantly accelerated healing from day 7 onward and heal significantly faster than control-treated wounds in diabetic mice. Deferoxamine-treated wounds and dimethyloxalylglycine-treated wounds heal significantly faster than control-treated wounds in aged mice. In deferoxamine (10 mg/mL)-treated TG mice, there is a decrease in both soluble and insoluble Aβ40 and Aβ42. Both pGSK3β and β-catenin are significantly increased by approximately 50% in the deferoxamine-treated mice.

安全信息

MSDS信息

去铁铵 价格(试剂级)

去铁铵 上下游产品信息