L-刀豆氨酸硫酸盐 CAS#: 2219-31-0

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L-刀豆氨酸硫酸盐

生物活性靶点体外研究体内研究 用途与合成方法 MSDS L-刀豆氨酸硫酸盐价格(试剂级) 上下游产品信息

中文名称	L-刀豆氨酸硫酸盐
中文同义词	L-刀豆氨酸硫酸盐水合物;4-胍氧丁胺酸 硫酸盐;L-刀豆氨酸硫酸盐(>98%,BR);NO SYNTHASE抑制剂(L-CANAVANINE SULFATE);L-刀豆氨酸硫酸盐;硫酸-L-刀豆氨基酸;刀豆氨酸;L-硫酸刀豆氨酸
英文名称	L-Canavanine sulfate
英文同义词	canavanine sulphate;L-canavanine sulfate crystalline;L-Canavanine Sulfate, Canavalia ensiformis;l-α-amino-γ-(guanidinooxy)butyric acid sulfate salt;CANAVANINE SULFATE, L-(RG);L-CANAVANINE SULFATE HYDRATE;L-CANAVANINE SULFATE;CANAVANINE SULFATE
CAS号	2219-31-0
分子式	C5H14N4O7S
分子量	274.25
EINECS号	218-728-4
相关类别	生化试剂;合成;其他生化试剂;植物提取物;细胞生物学试剂;中药对照品;化工原料;amino acid derivative;Amino Acids & Derivatives;Amino  Acids;Inhibitors;Nitric Oxide Reagents;Amino Acids;Biochemistry;Hydroxylamines;Hydroxylamines (N-Substituted);Hydroxylamines (O-Substituted);non-Proteinorganic Amino Acids
Mol文件	2219-31-0.mol
结构式

L-刀豆氨酸硫酸盐 性质

L-刀豆氨酸硫酸盐 用途与合成方法

生物活性

L-Canavanine sulfate 是诱导型 NO 合酶 (NO synthase) 的选择性抑制剂。

靶点

NO synthase

体外研究

L-Canavanine sulfate (L-CAV) causes only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC     ₅₀    values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC     ₅₀    of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells     in vitro    . In arginine-free media, IC     ₅₀    of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; and 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hardly toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells.

体内研究

Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20 mm Hg, returns blood pressure to near basal levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic rats dosed with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n=7). L-canavanine inhibits DNA synthesis by Li 210 cells     in vivo    and significantly increases the lifespan of animals bearing the Li 210 leukemia. An optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. The therapeutic dose range is narrow, and a dose of 24 g/kg causes death due to drug toxicity.

安全信息

MSDS信息

L-刀豆氨酸硫酸盐 价格(试剂级)

L-刀豆氨酸硫酸盐 上下游产品信息