3-甲基亚磺酰丙基异硫氰酸酯 CAS#: 505-44-2

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3-甲基亚磺酰丙基异硫氰酸酯

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 3-甲基亚磺酰丙基异硫氰酸酯价格(试剂级) 上下游产品信息

中文名称	3-甲基亚磺酰丙基异硫氰酸酯
中文同义词	3-甲基亚磺酰丙基异硫氰酸酯;化合物 T15544;化合物IBERIN
英文名称	IBERIN
英文同义词	IBERIN;1-isothiocyanato-3-(methylsulfinyl)propane;3-methylsulphinylpropylisothiocyanate;isothiocyanicacid,3-(methylsulfinyl)propylester;1-ISOTHIOCYANATO-3-(METHYLSULPHINYL)-PROPANE;3-(Methylsulfinyl)propyl isothiocyanate;Methyl(3-isothiocyanatopropyl) sulfoxide;3-methylsulfinylpropylimino(thioxo)methane
CAS号	505-44-2
分子式	C5H9NOS2
分子量	163.26
EINECS号
相关类别
Mol文件	505-44-2.mol
结构式

3-甲基亚磺酰丙基异硫氰酸酯 性质

3-甲基亚磺酰丙基异硫氰酸酯 用途与合成方法

生物活性

Iberin (NSC 321801) 是萝卜硫素的亚砜类似物，是天然存在的异硫氰酸酯家族的成员。抑制 HL60 细胞的 IC50 值为 2.3 μM。Iberin 诱导凋亡 (apoptosis)。

靶点

体外研究

Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9.

体内研究

Iberin is tested in an     in vivo    foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues.

安全信息

MSDS信息

3-甲基亚磺酰丙基异硫氰酸酯 价格(试剂级)

3-甲基亚磺酰丙基异硫氰酸酯 上下游产品信息