蛙皮素 CAS#: 31362-50-2

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蛙皮素

生物活性体外研究 用途与合成方法 MSDS 蛙皮素价格(试剂级) 上下游产品信息

中文名称	蛙皮素
中文同义词	黄蛙素;两栖蓝素;蛙皮素,胃泌素;铃蟾肽;蛙皮素;蛙皮素, ≥97% (HPLC);BOMBESIN ACETATE SALT HYDRATE 蛙皮素;BOMBESIN肽
英文名称	Bombesin
英文同义词	Bombesin  hydrate  acetate  salt;Bombesin acetate salt hydrate;2-l-glutamine-6-l-asparagine-alytesi;bombesin acetate;Bombesin, Free Base;BOMBESIN SYNTHETIC >97% STIMULATES GASTR IN RE;BOMBESIN;bombesin acetate hydrate
CAS号	31362-50-2
分子式	C71H110N24O18S
分子量	1619.85
EINECS号
相关类别	多肽类;细胞生物学;蛋白质/多肽;细胞信号和神经生物学;多肽;多肽-客户肽;目录肽;目录多肽;Neuromedins and related;Peptide
Mol文件	31362-50-2.mol
结构式

蛙皮素 性质

蛙皮素 用途与合成方法

生物活性

Bombesin是一种最初从青蛙皮肤中分离的十四肽; 在胃泌素释放和G蛋白受体活化中起重要作用。

体外研究

Bombesin is a tetradecapeptide with a COOH terminus ending in Gly-His-Leu-Met-NH2 and subsequently is shown to closely resemble two mammalian bombesin -related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB). Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is also found in mammalian brain, with its highest concentration in the hypothalamus. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor (IC     ₅₀    =1 nM).

多肽

蛙皮素是由14个氨基酸组成的多肽，是从铃蟾皮肤提取的一种多肽物质。蛙皮素的主要生理功能是通过神经调节促进胃窦胃泌素的释放和胃酸分泌，促进胰酶分泌，刺激胆囊收缩。同时弹力蛋白还能刺激胰岛素、胰高血糖素和胰多肽的释放，促进红细胞生成素的释放，刺激肾素一血管紧张素系统，并有升高血糖、调节体温和收缩支气管的作用。

参考质量标准

外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%

安全信息

MSDS信息

蛙皮素 价格(试剂级)

蛙皮素 上下游产品信息