食欲肽B (人) CAS#: 205640-91-1

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食欲肽B (人)

生物活性靶点体外研究体内研究

中文名称	食欲肽B (人)
中文同义词	食欲肽B(人) ≥98%;食欲肽B(人) ≥98%, ≥98% (HPLC);人OREXIN B;食欲肽B (人);RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 (TRIFLUOROACETATE SALT);食欲素B(人类)三氟乙酸盐;化合物 OREXIN B, HUMAN
英文名称	OREXIN B (HUMAN)
英文同义词	REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2;Orexin B (huMan) Hypocretin-2 (huMan);OREXIN B HUMAN ≥98%;Orexin B (human), ≥98% (HPLC);PubChem ID: 90479794;ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;HYPOCRETIN-2;HYPOCRETIN-2, HUMAN
CAS号	205640-91-1
分子式	C123H212N44O35S
分子量	2899.34
EINECS号
相关类别	其他生化试剂;生化试剂;多肽;标准品;proteins;Peptide;Orexin receptor
Mol文件	205640-91-1.mol
结构式

食欲肽B (人) 性质

食欲肽B (人) 用途与合成方法

生物活性

Orexin B, human是 Orexin 受体的内源性激动剂，与OX1和OX2结合的 Ki 值分别为 420 和 36 nM。

靶点

Ki: 420 nM (OX1), 36 nM (OX2)

体外研究

Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC     ₅₀    of 36 nM in the binding assay and an EC     ₅₀    of 60 nM in the [Ca     ²⁺    ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC     ₅₀    in the competitive binding assay and the EC     ₅₀    in the [Ca     ²⁺    ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

体内研究

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.

参考质量标准

外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%

安全信息

MSDS信息

食欲肽B (人) 上下游产品信息