凝血酶受体兴奋剂 CAS#: 137339-65-2

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凝血酶受体兴奋剂

背景生物活性体外研究 用途与合成方法 MSDS 凝血酶受体兴奋剂价格(试剂级) 上下游产品信息

中文名称	凝血酶受体兴奋剂
中文同义词	凝血酶受体兴奋剂;凝血酶受体激动剂肽-14;凝血酶受体激动剂;凝血酶受体活化因子肽;凝血酶受体激动剂 THROMBIN RECEPTOR AGONIST TRAP-14
英文名称	SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-LYS-TYR-GLU-PRO-PHE
英文同义词	thrombinreceptorpeptide(42-55;ser-phe-leu-leu-arg-asn-pro-asn-asp-*lys-tyr-glu-;SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-*LYS -TYR-GLU-PR;HUMAN TNFSF5;HUMAN TRAP;HUMAN SOLUBLE CD40 LIGAND;HUMAN T-BAM;HUMAN SCD40 LIGAND
CAS号	137339-65-2
分子式	C81H118N20O23
分子量	1739.92
EINECS号
相关类别	生化试剂;多肽;细胞生物学-细胞氧化应激;试剂盒-Elisa试剂盒;大环化合物;标准品;Peptide
Mol文件	137339-65-2.mol
结构式

凝血酶受体兴奋剂 性质

凝血酶受体兴奋剂 用途与合成方法

背景

TRAP-14是人工合成的thrombin受体激动剂多肽，也是一种凝血酶受体兴奋剂多肽，序列中含有14个氨基酸，多肽具有较好的亲水性。

生物活性

Sfllrnpndkyepf 是人工合成的 thrombin 受体激动剂肽段。

体外研究

Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence Sfllrnpndkyepf. This peptide (TRP-14) may signal a variety of thrombin's responses. Sfllrnpndkyepf, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. Sfllrnpndkyepf, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. Sfllrnpndkyepf is the minimal peptide length which retains full activity in inducing [     ¹⁴    C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.

安全信息

MSDS信息

凝血酶受体兴奋剂 价格(试剂级)

凝血酶受体兴奋剂 上下游产品信息