MM 07 CAS#: 1876450-21-3

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MM 07

生物活性靶点体外研究体内研究 用途与合成方法 MSDS MM 07价格(试剂级) 上下游产品信息

中文名称	MM 07
中文同义词	APELIN受体多肽;激动剂多肽MM 07;MM 07 三氟乙酸盐;MM 07 TFA
英文名称	MM 07
英文同义词	MM 07;CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6);MM 07 TFA
CAS号	1876450-21-3
分子式	C67H106N22O14S3
分子量	1539.91
EINECS号
相关类别	目录肽
Mol文件	1876450-21-3.mol
结构式

MM 07 性质

MM 07 用途与合成方法

生物活性

MM 07 是一种有偏倚性的 apelin 受体 (apelin receptor) 激动剂，在 CHO-K 细胞中的 KD 值为 300 nM，在人心脏中的 KD 值为 172 nM。

靶点

KD: 300 nM (apelin receptor in CHO-K1 cells), 172 nM (apelin receptor in human heart).

体外研究

MM 07 competes with nanomolar affinities for binding of [Glp     ⁶⁵    ,Nle     ⁷⁵    ,Tyr     ⁷⁷    ] [     ¹²⁵    I]apelin-13 to human apelin receptors in CHO-K1 cells (K     _D    , 300 nM) and human heart (K     _D    , 172 nM, n=3).

体内研究

MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr     ¹    ]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr     ¹    ]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr     ¹    ]apelin 13 and MM 07 increases peak velocity above basal levels.

安全信息

MSDS信息

MM 07 价格(试剂级)

MM 07 上下游产品信息