维生素 B12A CAS#: 59461-30-2

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维生素 B12A

生物活性体外研究体内研究 用途与合成方法 MSDS 维生素 B12A价格(试剂级) 上下游产品信息

中文名称	维生素 B12A
中文同义词	羟钴胺单盐酸盐;化合物 T13731;维生素 B12杂质13 (维生素 B12 EP 杂质H 盐酸盐);维生素 B12 EP杂质H 盐酸盐
英文名称	hydroxocobalamin monohydrochloride
英文同义词	Einecs 261-772-4;Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride;hydroxocobalamin monohydrochloride;Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride;Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1);Vitamin B12a monohydrochloride;Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC);Cyanocobalamin Impurity 13 (Cyanocobalamin EP Impurity H Hydrochloride)
CAS号	59461-30-2
分子式	C62H89ClCoN13O15P
分子量	1381.83
EINECS号	261-772-4
相关类别
Mol文件	59461-30-2.mol
结构式

维生素 B12A 性质

维生素 B12A 用途与合成方法

生物活性

Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) 是一种可注射的天然维生素 B12，具有良好的不良反应特征，可作为维生素 B12 缺乏症 (包括恶性贫血) 的膳食补充剂。

体外研究

The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO     in vitro    .

体内研究

Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).  
 More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.

安全信息

MSDS信息

维生素 B12A 价格(试剂级)

维生素 B12A 上下游产品信息