5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 CAS#: 102120-99-0

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5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐

生物活性靶点体外研究 用途与合成方法 MSDS 5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐价格(试剂级) 上下游产品信息

中文名称	5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐
中文同义词	5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐;盐酸罗替高汀;罗替高汀-D7盐酸;消旋罗替戈汀;罗替高汀消旋体;化合物 T12676;6-(PROPYL(2-(THIOPHEN-2-YL)ETHYL)AMINO)-5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL HYDROCHLORIDE;罗替戈汀外消旋盐酸盐
英文名称	rac-Rotigotine Hydrochloride
英文同义词	Rotigotine Impurity 2（Rotigotine Racemate HCl）;Rotigotine-d7 HCl;rac-Rotigotine Hydrochloride;1-Naphthalenol,5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-,hydrochloride;N 0437 hydrochloride;5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-1-naphthalenol Hydrochloride;1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]aMino]-, (Hydrochloride) (1:1);(Rac) Rotigotine hydrochloride,(Rac)Rotigotine hydrochloride
CAS号	102120-99-0
分子式	C19H26ClNOS
分子量	351.93
EINECS号
相关类别	Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol文件	102120-99-0.mol
结构式

5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 性质

5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 用途与合成方法

生物活性

(Rac)-Rotigotine hydrochloride 是 Rotigotine 的外消旋体。Rotigotine 是 dopamine receptor 激动剂，是 5-HT1A receptor 的部分激动剂，以及 α2B-adrenergic receptor 的拮抗剂，Ki 值分别为 0.71 nM (dopamine D3 receptor)，4-15 nM (D2，D5，D4 receptors)，83 nM (dopamine D1 receptor)。

靶点

体外研究

Rotigotine has a 10-fold selectivity for D3 (pK     _i    =9.2) receptors compared with D2, D4 and D5 (pK     _i    =8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pK     _i    =7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC     ₅₀    respectively: 9.0, 9.4-8.6, 9.7).Rotigotine (10 µM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 µM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone..

安全信息

MSDS信息

5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 价格(试剂级)

5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐 上下游产品信息