培美曲塞二钠盐 CAS#: 137281-23-3

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培美曲塞二钠盐

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 培美曲塞二钠盐价格(试剂级) 上下游产品信息 专题

中文名称	培美曲塞二钠盐
中文同义词	培美曲塞酸;二钠培美曲塞;N-[4-[2-(2-氨基-4,7-二氢-4-氧代-3H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰基]-L-谷氨酸;培美曲唑;N-[4-[2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-D]嘧啶-5-基)乙基]苯甲酰基]-L-谷氨酸;培美曲塞酸 (N-(4-[2-(2-氨基-4,7-二氢-4-氧-1H-吡咯[2,3-D]嘧啶-5-基)乙基]苯甲酰)-L-谷氨酸);N-[4-[2-(2-胺基-4,7-二氢-4-氧-1H吡咯[2,3-D]嘧啶-5基)乙基]苯甲酰]-L-谷氨酸;培美曲赛杂质1
英文名称	Pemetrexed
英文同义词	(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid;PeMetrexed-13C5;PeMetrexed-15C5;N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid);N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid;(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi;N-[4-[2-(2-Amino-4,7;(2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid
CAS号	137281-23-3
分子式	C20H21N5O6
分子量	427.41
EINECS号	680-625-9
相关类别	原料药;中间体;医药原料;培美中六;小分子抑制剂;培美曲塞二钠中间体;医药中间体;细胞凋亡;药物杂质及中间体;化药杂质-培美曲塞;原料药及中间体;化学试剂;API;CIALIS;Anti-cancer & immunity;标准品;生物化工
Mol文件	137281-23-3.mol
结构式

培美曲塞二钠盐 性质

培美曲塞二钠盐 用途与合成方法

生物活性

Pemetrexed (LY231514) 是一种叶酸拮抗剂 (antifolate)。Pemetrexed (LY231514) 抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)，Ki 分别为 1.3 nM，7.2 nM 和 65 nM。

靶点

Ki: 1.3 nM (TS), 7.2 nM (DHFR), 65 nM (GARFT)

体外研究

Pemetrexed (LY231514) disodium is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multipie inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. Pemetrexed (LY231514) is one of the best substrates that is known for the enzyme FPGS (K     _m    =1.6 μM and V     _max    /K     _m    =621). It is likely that polyglutamation and the polyglutamated metabolites of LY231514 play profound roles in determining both the selectivity and the antitumor activity of this novel agent. Whereas LY23l5l4 only moderately inhibits TS (K     _i    =340 nM, recombinant mouse), the pentaglutamate of LY23l5l4 is 100-fold more potent (K     _i    =3.4 nM), making LY231514 one of the most potent folate-based TS inhibitors.

体内研究

The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment.

安全信息

MSDS信息

培美曲塞二钠盐 价格(试剂级)

培美曲塞二钠盐 上下游产品信息