4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯 基本信息
中文名称 | 4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯 |
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中文同义词 | 4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯(阿哌沙班中间体);乙基 1H-吡唑并[3,4-C]吡啶-3 - 羧酸的酸,4,5,6,7 - 四氢-1 - (4 - 甲氧基苯基)-6 - (4 - 硝基苯基)-7 - 氧代乙基酯;阿哌沙班杂质 G;进口资料代码-BMS-778960-01;4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-;4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸;4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯(阿哌沙班中间体) 10G;4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯 |
英文名称 | ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate |
英文同义词 | 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester;ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate;4,5,6,7-Tetrahydro-1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxyl;Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3;1H-Pyrazolo[3,4-c]pyridine-3-carboxylicacid,4,5,6,7-tetrahydro-1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-,ethylester;Apixaban iMpurityG;Apixaban impurity BMS-589154;4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl este |
CAS号 | 536759-91-8 |
分子式 | C22H20N4O6 |
分子量 | 436.42 |
EINECS号 | 611-033-0 |
相关类别 | 阿哌沙班杂质;杂质对照品;合成材料中间体;对照品-杂质对照品 |
Mol文件 | 536759-91-8.mol |
结构式 |
4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯 性质
熔点 | 190-192°C |
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沸点 | 658.7±55.0 °C(Predicted) |
密度 | 1.40 |
蒸气压 | 0Pa at 25℃ |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 氯仿(微溶)、乙酸乙酯(微溶) |
酸度系数(pKa) | -3.80±0.20(Predicted) |
形态 | 固体 |
颜色 | 浅棕色至浅橙色 |
InChI | InChI=1S/C22H20N4O6/c1-3-32-22(28)19-18-12-13-24(14-4-6-16(7-5-14)26(29)30)21(27)20(18)25(23-19)15-8-10-17(31-2)11-9-15/h4-11H,3,12-13H2,1-2H3 |
InChIKey | RQNAOIQEGPVYTC-UHFFFAOYSA-N |
SMILES | C1(=O)N(C2=CC=C([N+]([O-])=O)C=C2)CCC2C(C(OCC)=O)=NN(C3=CC=C(OC)C=C3)C1=2 |
LogP | 3.59 at 23℃ and pH6.57 |
4,5,6,7-四氢-1-(4-甲氧基苯基)-6-(4-硝基苯基)-7-氧代-1H-吡唑并[3,4-C]吡啶-3-羧酸乙酯 用途与合成方法
用途
阿派沙班中间体