(+)-AEROPLYSININ-1 CAS#: 28656-91-9

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(+)-AEROPLYSININ-1

生物活性靶点体外研究 用途与合成方法 MSDS (+)-AEROPLYSININ-1价格(试剂级) 上下游产品信息

中文名称	(+)-AEROPLYSININ-1
中文同义词	(+)-AEROPLYSININ-1;化合物 T23645;化合物 AEROPLYSININ 1
英文名称	(+)-AEROPLYSININ-1
英文同义词	(+)-aeroplysinini;(1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr;aeroplysinini;AEROPLYSININ;(+)-AEROPLYSININ-1;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;AEROPLYSININ, APLYSINA AEROPHOBA
CAS号	28656-91-9
分子式	C9H9Br2NO3
分子量	338.98
EINECS号
相关类别
Mol文件	28656-91-9.mol
结构式

(+)-AEROPLYSININ-1 性质

(+)-AEROPLYSININ-1 用途与合成方法

生物活性

Aeroplysinin 1 ((+)-Aeroplysinin-1)，从海洋海绵中分离出的次生代谢产物，对革兰氏阳性细菌 (bacteria) 显示出有效的抗生素作用，并具有针对 HIV-1 的抗病毒活性 (IC50=14.6 μM)。Aeroplysinin 1 具有抗炎，抗血管生成和抗肿瘤活性。Aeroplysinin 1诱导内皮细胞凋亡 (apoptosis)。

靶点

体外研究

Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC     ₅₀    s ranging from 2.3 to 17 μM.  
 Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity.Aeroplysinin 1 inhibits     P. phosphoreum    ,     C. wailesii    ,     P. minimum    and HIV with IC     ₅₀    s of 3.5, 5.6, 7.0 and 14.6 μM. Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC     ₅₀    s ranging from 2.6 to 4.7 μM.  
 (+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro.

安全信息

MSDS信息

(+)-AEROPLYSININ-1 价格(试剂级)

(+)-AEROPLYSININ-1 上下游产品信息