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| 中文名: | ;(R)-4-(4-((4'-氯-[1,1'-联苯]-2-基)甲基)哌嗪-1-基)-N-((4-((4-(二甲氨基)-1-(苯硫基)丁基-2-基)氨基)-3-硝基苯基)磺酰)苯甲酰胺 |
| 中文别名: | 4-[4-[(4‘-氯[1,1‘-联苯]-2-基)甲基]-1-哌嗪基]-N-[[4-[[(1R)-3-(二甲基氨基)-1-[(苯硫基)甲基]丙基]氨基]-3-硝基苯基]磺酰基]苯甲酰胺;4-[4-[(4‘-氯-联苯-2-基)甲基]哌嗪-1-基]-N-[[4-[[(1R)-3-(二甲胺基)-1-[(苯基硫基)甲基]丙基]氨基]-3-硝基苯基]磺酰基]苯甲酰胺 |
| 英文名称： | ABT-737 |
| 英文别名： | ABT-737 |
| CAS No.: | 852808-04-9 |
| 分子式: | C42H45ClN6O5S2 |
| 分子量: | 813.43 |
| 性状: | 熔点 152-154°C储存条件 -20°C Freezer |
| 储存: | |
| 安全术语: | |
| 风险术语: | |
| 危险品标志: | |
| 危险品运输编号: | |
| 用途: | ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance, [1-3] inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells. The ABT-737 single-agent LC90 values ranged from 100 nM for COG-LL-319 and RS4;11 cells to low micromolar concentrations for the other five ALL cell lines. |
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