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| 中文名: | 恩曲他滨;恩曲他滨 |
| 中文别名: | 恩曲他滨;5-氟-1-(2R,5S)-[2-羟甲基-1,3-氧硫环-5-酰]胞嘧啶;依曲西他滨;盐酸恩曲他滨;恩曲他滨 EMTRIVA;恩曲他滨 |
| 英文名称： | Emtricitabine(Emtriva) |
| 英文别名： | EMTRICITABINE;Emtriva;Coviracil;BW1592;BW-1592;BW 1592;Atripla; |
| CAS No.: | 143491-57-0 |
| 分子式: | C8H10FN3O3S |
| 分子量: | 247.25 |
| 性状: | 属性存贮条件储存温度-20°C描述产品介绍Emtricitabine 是一种核苷逆转录酶抑制剂，IC50为27.7 μM用途A HIV-1 reverse transcriptase (HIV-1 RT) inhibitor生化机理Emtricitabine is a nucleoside analogue which inhibits the reverse nucleoside transcriptase enzyme. Structurally this antiviral agent is similar to Lamivudine. This agent is effective at targeting HIV and HBV viruses since these viruses replicate in a reverse transcriptase manner. Studies indicate that the structure of Emtricitabine, specifically the unnatural β-L structural configuration produce greater antiviral effects in vitro on HIV and HBV than other antiviral agents. To activate Emtricitabine it needs to undergo multistep intracellular phosphorylation by various cellular kinases. These studies suggest that Emtricitabine competitively inhibits HIV-1 reverse transcriptase (HIV-1 RT) and can cause termination of DNA chain elongation in the virus via incorporation into the viral genome.包装E125328-25mg,E125328-250mg in glass bottle |
| 储存: | 储存温度-20°C |
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| 用途: | Emtricitabine(Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM. [1] The drug works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA. By interfering with this process, which is central to the replication of HIV, emtricitabine can help to lower the amount of HIV, or "viral load", in a patient’s body and can indirectly increase the number of immune system cells (called T cells or CD4+ T-cells). Both of these changes are associated with healthier immune systems and decreased likelihood of serious illness. [2] |
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