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![2-(2-(2-(2-(4-(苯并[d]噻唑-2-基)苯氧基)乙氧基)乙氧基)乙氧基)乙醇](https://yunshiji.oss-cn-shenzhen.aliyuncs.com/cas/2274723-90-7.png "2-(2-(2-(2-(4-(苯并[d]噻唑-2-基)苯氧基)乙氧基)乙氧基)乙氧基)乙醇")
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| 中文名: | 匹莫苯丹;匹莫苯丹 |
| 中文别名: | Acardi, pimobendane;匹莫苯; 匹莫苯丹; 6-[2-(4-甲氧基苯基)-1H-苯并咪唑-5-基]-5-甲基-4,5-二氢-3(2H)-哒嗪酮 |
| 英文名称： | Pimobendan(Vetmedin) |
| 英文别名： | Acardi, pimobendane;4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone |
| CAS No.: | 74150-27-9 |
| 分子式: | C19H18N4O2 |
| 分子量: | 334.37 |
| 性状: | 属性溶解性DMSO 67 mg/mL (200 mM); 水<1 mg/mL (<1 mM) ; 乙醇 5 mg/mL (14 mM)存贮条件储存温度-20°C描述产品介绍Pimobendan是一种磷酸二酯酶III(PDE III)选择性抑制剂，IC50为0.32 μM。 |
| 储存: | 储存温度-20°C |
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| 危险品运输编号: | |
| 用途: | Pimobendan(Vetmedin) is a Ca(2+) sensitizer with an IC50 of 26 μM and a selective phosphodiesterase III inhibitor with an IC50 of<1 μM. [1] The inhibitory effects of pimobendan on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. Pimobendan decreased the catecholamine secretion (IC(50)=29.5 μM) elicited by carbachol, an agonist at nicotinic acetylcholine receptors, but not that elicited by veratridine, an activator of voltage-dependent Na(+) channels, or by high K(+), an activator of voltage-dependent Ca(2+) channels. Pimobendan also inhibited carbachol-induced influx of Na(+) (IC(50)=25.9 μM) and Ca(2+) (IC(50)=26.0 μM), but not veratridine-induced Na(+) influx or high K(+)-induced Ca(2+) influx. [2] |
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