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| 中文名: | ;6-[[5-氟-2-[(3,4,5-三甲氧基苯基)氨基]-4-嘧啶基]氨基]-2,2-二甲基-2H-吡啶并[3,2-b]-1,4-噁嗪-3(4H)-酮苯磺酸盐 |
| 中文别名: | 6-[[5-氟-2-[(3,4,5-三甲氧基苯基)氨基]-4-嘧啶基]氨基]-2,2-二甲基-2H-吡啶并[3,2-B]-1,4-恶嗪-3(4H)-酮苯磺酸盐 |
| 英文名称： | R406 |
| 英文别名： | R406 |
| CAS No.: | 841290-81-1 |
| 分子式: | C22H23FN6O5.C6H6O3S |
| 分子量: | 628.63 |
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| 用途: | R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 has shown efficacy in a number of animal models of immune disorders. R406 inhibited airway hyperresponsiveness (AHR) and airway inflammation in mice, at least in part through alteration of mast cell and dendritic cell functions. Similarly, R406 treatment ameliorated joint inflammation in a number of rodent models of rheumatoid arthritis and also blocked JNK-mediated gene expression in human synoviocytes, suggesting a possible role in the treatment of rheumatoid arthritis. [1][2] |
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