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| 中文名: | LDN-193189;4-(6-(4-(哌嗪-1-基)苯基)吡唑并[1,5-a]嘧啶-3-基)喹啉 |
| 中文别名: | 4-[6-(4-(哌嗪-1-基)苯基]吡唑并[1,5-a]嘧啶-3-基)喹啉; |
| 英文名称： | LDN 193189 |
| 英文别名： | LDN-193189; DM-3189; DM 3189;4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| CAS No.: | 1062368-24-4 |
| 分子式: | C25H22N6 |
| 分子量: | 479.4 |
| 性状: | 属性溶解性DMSO 0.01 mg/mL (<1 mM); Water 0.01 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)存贮条件储存温度-20°C描述产品介绍LDN-193189是一种选择性的BMP信号通路抑制剂，抑制BMP I型受体ALK2和ALK3的转录活性，IC50分别为5 nM和30 nM，作用于BMP比作用于TGF-β选择性高200倍。生化机理 LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors. |
| 储存: | 储存温度-20°C |
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