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| 中文名: | 盐酸马尼地平;3-(2-(4-苯基哌嗪-1-基)乙基)5-甲基2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯二盐酸盐 |
| 中文别名: | |
| 英文名称： | Manidipine HCl (CV-4093) |
| 英文别名： | Manidipine HCl (CV-4093) |
| CAS No.: | 89226-75-5 |
| 分子式: | C35H38N4O6.2HCl |
| 分子量: | 683.62 |
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| 用途: | Manidipine HCl (CV-4093) is a hydrochloride salt of manidipine that is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. Manidipine HCl (CV-4093) causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine HCl (CV-4093) is used clinically as an antihypertensive. [1][2][3] Manidipine HCl (CV-4093) suppressed the DNA synthesis of vascular smooth muscle cells (VSMC) dose dependently at concentrations of more than 10 nM. Mandipine hydrochloride (1 μM) suppressed proliferation of VSMC to 50% of the control value. Manidipine hydrochloride stimulated the synthesis of GAG at concentrations above 0.01 nM. Manidipine hydrochloride (10 nM) stimulated synthesis of glycosaminoglycans(GAG) to 450% of control. [4]br /[1] http://en.wikipedia.org/wiki/Manidipine |
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