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| 中文名: | AG-490;(E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺 |
| 中文别名: | 酪氨酸磷酸化抑制剂AG 490 |
| 英文名称： | AG-490 |
| 英文别名： | AG-490 |
| CAS No.: | 133550-30-8 |
| 分子式: | C17H14N2O3 |
| 分子量: | 294.3 |
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| 用途: | AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8μM for EGFR and JAK, respectively. It inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo. It selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. It inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. It displays apoptotic and antiproliferative properties with IC50 of 1.7, 2.8 and 6.1 μM in 2E8, Baf/3 and Jurkat cells, respectively. [1][2]br /[1] J Immunol. 1999 Apr 1;162(7):3897-904. |
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