马来酸维吖啶;马来酸维吖啶;9-氨基-1,2,3,4-四氢吖啶-1-醇马来酸盐;118909-22-1;

属性溶解性Soluble in water (5 mg/mL warm), DMSO (25 mg/mL), and ethanol (10 mg/mL).存贮条件储存温度-20°C，充氩储存描述别名;Velnacrine maleate;9-Amino-1,2,3,4-tetrahydro-1-acridinol (2Z)-2-butenedioate;9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate生化机理Hydroxytacrine maleate is a cholinesterase inhibitor and a potential Alzheimer’s therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to tacrine (THA) except that it is far less toxic and without measurable liver toxicity in humans. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Major form of metabolism is in the liver via hydroxylation of benzylic carbon by CYP450. This forms the major metabolite 1-hydroxy-tacrine (velnacrine) which is still active. Hydroxytacrine maleate is an inhibitor of AChE.应用A cholinesterase inhibitor that exhibits a biochemical profile very similar to tacrine