详细说明
| Replacement Information |
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重要规格表
| Analytes Available | Species Reactivity | Key Applications | Detection Methods |
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| α2-Macroglobulin, Apo Al, Apo CIII, Apo E, Complement C3, Complement Factor H | H | Mplex | Luminex xMAP |
| Description | |
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| Catalogue Number | HNDG1MAG-36K |
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| Description | MILLIPLEX MAP Human Neurodegenerative Disease Magnetic Bead Panel 1 - Neuroscience Multiplex Assay |
| Overview | The MILLIPLEX® MAP Human Neurodegenerative Magnetic Bead Panel 1 (HNDG1MAG-36K) is to be used for the simultaneous quantification of the following 7 analytes in any combination: α-2-Macroglobulin, Apo A1, Apo CIII, Apo E, Complement C3 and Complement Factor H. This kit may be used for the analysis of all above analytes in human serum, plasma, and cerebrospinal fluid samples. References: Acta Neuropathol Commun. 2016 Feb 17;4:14. doi: 10.1186/s40478-016-0277-8. CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease. Hu WT, Watts KD, Tailor P, Nguyen TP, Howell JC, Lee RC, Seyfried NT, Gearing M, Hales CM, Levey AI, Lah JJ, Lee EK; Alzheimer’s Disease Neuro-Imaging Initiative. |
| Background Information | Neurodegenerative disease is a condition characterized by the deterioration of neurons or their myelin sheath over time in the brain and/or spinal cord. These neurons are responsible for such everyday activities as processing sensory information, making decisions, and controlling movement. Because these cells are not easily regenerated, excessive cumulative damage can lead to age-related diseases such as Alzheimer's and Parkinson's disease, as well as other conditions such as amyotrophic lateral sclerosis (ALS) and epilepsy. These disorders are devastating and expensive, both on a personal and global level, and as population demographics continue to change, a therapeutic solution is critical. Consequently, research is underway to identify biomarkers that will help scientists not only understand the pathogenesis of neurodegenerative disease, but also identify people with these disorders before the onset of symptoms and potentially provide new therapeutic tools. |
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| Product Information | |
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| Detection method | Luminex xMAP |
| Configuration | Design your multiplex kit by choosing available analytes within this panel. |
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| Panel Type | MAGNETIC Neuroscience |
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| Application | The analytes available for this multiplex kit are: α2-Macroglobulin, Apo Al, Apo CIII, Apo E, Complement C3 and Complement Factor H. |
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| Application Notes | • This is a 2-hour incubation assay. • This assay requires 25 μL of 1:40,000 diluted serum/plasma or 1:400 diluted CSF per well. |
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| Assay Panel | Everything you need in a single kit. |
| Cross Reactivity | Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible. |
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| Storage Conditions | Recommended storage for kit components is 2 - 8°C. |
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| Material Size | 96-well plate |
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