详细说明
| Replacement Information |
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重要规格表
| Analytes Available | Species Reactivity | Key Applications | Detection Methods |
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| GM-CSF, sCD137, IFNγ, sFas, sFasL, Granzyme A, Granzyme B, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, MIP-1α, MIP-1β, TNF-α, Perforin | H | Mplex | Luminex xMAP |
| Description | |
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| Catalogue Number | HCD8MAG15K17PMX |
| Trade Name |
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| Description | MILLIPLEX MAP Human CD8+ T Cell Magnetic Bead Panel Premixed 17 Plex - Immunology Multiplex Assay |
| Overview | The MILLIPLEX MAP Human CD8+ T Cell Magnetic Bead Panel enables you to focus on the therapeutic potential of Human CD8+ T Cell analytes. Coupled with the Luminex® xMAP® platform in a magnetic bead format, you receive the advantage of ideal speed and sensitivity, allowing quantitative multiplex detection of several analytes simultaneously, which can dramatically improve productivity. The MILLIPLEX MAP Human CD8+ T Cell Magnetic Bead Panel is the most versatile system available for Mouse CD8+ T Cell research. MILLIPLEX MAP offers you the ability to: • Select a 17-plex premixed option or • Choose any combination of analytes from our panel of 17 analytes to design a custom kit that better meets your needs. • A convenient “all-in-one” box format gives you the assurance that you will have all the necessary reagents you need to run your assay. |
| Background Information | CD8+ T cells (also known as cytotoxic T cells, cytolytic T cells and killer T cells) belong to a sub-group of T cells capable of inducing the death of infected somatic or tumor cells. T cells that bind weakly to Major Histocompatibility Complex (MHC) self-antigens are positively selected into single-positive CD4+ or CD8+ T cells in the thymus. Those CD8+ T cells that survive and mature after activation become cytotoxic cells, expressing T-cell receptors (TCRs) capable of recognizing specific antigenic peptides bound to Class I MHC molecules and the glycoprotein CD8. Affinity between the CD8 protein and the MHC molecule helps to keep the cytotoxic T cell and target closely bound during antigen specific activation. Once activated, CD8+ T cells are generally classified as having a predefined cytotoxic role within the immune system and undergo IL-2 induced clonal expansion, which increases the number of cells specific for the target antigen. The CD8+ T cells then travel throughout the body in search of antigen-positive somatic/tumor cells. |
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| Product Information | |
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| Detection method | Luminex xMAP |
| Configuration | Premixed |
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| Panel Type | MAGNETIC Cytokines/Chemokines |
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| Application | Simultaneously analyze multiple cytokine and chemokine biomarkers with Bead-Based Multiplex Assays using the Luminex technology, in human serum, plasma and cell culture samples. |
| Key Applications |
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| Application Notes | • This is an overnight incubation assay requiring 25 µL of neat plasma or serum, or 25 μL cell culture supernatant per well. • This kit may be used for the analysis of all or any combination of the Human CD8+ T-Cell Panel analytes in serum, plasma or tissue/cell lysate and culture supernatant. |
| Biological Information | |
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| Specificity | Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible. |
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| Storage Conditions | Recommended storage for kit components is 2 - 8°C. |
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| Material Size | 96-well plate |
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