详细说明
| Replacement Information |
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| Description | |
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| Catalogue Number | CC1092 |
| Replaces | CC1029 |
| Brand Family | Chemicon® |
| Trade Name |
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| Description | Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human |
| Overview | Integrin alpha3beta1 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alpha3beta1 integrin. |
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| Product Information | |
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| Presentation | Purified protein in 150 Mm NaCl, 0.1 mM CaCl2, 1 mM MgCl2, 25 mM Tris-HCL, pH 7.4, 100 mM Octyl-b-D-glucopyranoside. No preservatives. |
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| Key Applications |
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| Application Notes | Electrophoresis, Immunoblotting, and Ligand Binding studies. Optimal working dilutions must be determined by end user. |
| Biological Information | |
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| Purity | >95% by SDS-PAGE |
| Entrez Gene Number |
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| Entrez Gene Summary | ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3'). |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P26006 # Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. SIZE: 1066 amino acids; 118698 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells. PTM: Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12- myristate 13-acetate stimulation. SIMILARITY: SwissProt: P26006 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. |
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| Usage Statement |
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| Storage Conditions | Maintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles |
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| Material Size | 25 µg |
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