详细说明
| Replacement Information |
|---|
| Description | |
|---|---|
| Catalogue Number | CC1023 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Human Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation |
| Overview | Integrin alphaVbeta5 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alphaVbeta5 integrin. . Product was tested and found negative for HIV and Hepatitis B. |
| References |
|---|
| Product Information | |
|---|---|
| Presentation | Purified protein inTris buffered saline with 100mM Octyl-β-D-glucopyranoside and sodium azide |
| Applications | |
|---|---|
| Key Applications |
|
| Application Notes | Electrophoresis Immunoblotting Ligand binding studies. Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Concentration | 433 μg/mL |
| Purity | >95% by SDS-PAGE (silver stain) |
| Entrez Gene Number |
|
| Entrez Gene Summary | ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. SIZE: 1048 amino acids; 116038 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 50 µg |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
粤公网安备44196802000105号
400-6226-992