详细说明
| Replacement Information |
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| Description | |
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| Catalogue Number | 12-355 |
| Brand Family | Upstate |
| Trade Name |
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| Description | SAMS Peptide |
| References |
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| Product Information | |
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| Presentation | sterile distilled water |
| Applications | |
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| Application | SAMS Peptide primarily used in Kinase Assays. |
| Key Applications |
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| Biological Information | |
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| Entrez Gene Number |
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| Entrez Gene Summary | This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. |
| Gene Symbol |
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| Protein Target | AMPK (α1, β1, γ1) |
| Target Sub-Family | CAMK |
| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: Q00266 # Catalyzes the formation of S-adenosylmethionine from methionine and ATP. COFACTOR: Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity). & Binds 1 potassium ion per subunit (By similarity). SIZE: 395 amino acids; 43648 Da SUBUNIT: Homotetramer (MAT-I) or homodimer (MAT-III). TISSUE SPECIFICITY: Expressed in liver. DISEASE: SwissProt: Q00266 # Defects in MAT1A are a cause of a form of hypermethioninemia [MIM:250850]; also called MAT I/III deficiency. The disease is characterized by fetid breath and dimethylsulfide excretion. Most mutations are transmitted in an autosomal recessive manner, but autosomal dominant inheritance has also been observed. The clinical consequences of hypermethioninemia are poorly understood. In some individuals, hypermethioninemia is apparently benign; in others, association of neurological problems with null mutations has been observed. SIMILARITY: SwissProt: Q00266 ## Belongs to the AdoMet synthetase family. |
| Physicochemical Information |
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| Product Usage Statements | |
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| Quality Assurance | Routinely evaluated by Peptide Phosphorylation Assay. SAMS Peptide was phosphorylated by AMP activated enzyme in the presence and absence of AMP. |
| Usage Statement |
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| Storage and Shipping Information | |
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| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
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| Material Size | 250 µg |
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