IL-16 (121aa) human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture te

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IL-16 (121aa) human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture te信息二维码

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产品介绍

    基本参数

    详细说明

    别名:   LCF (Lymphocyte Chemoattractant Factor)

      产品名称

      Biochem/physiol Actions

      IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Recombinant human IL-16 is a 12.4 kDa protein consisting of 121 amino acid residues.

      Reconstitution

      Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

      Physical form

      Lyophilized from 5 mM Sodium Phosphate, pH 5.5 + 0.5 mM DTT.

      General description

      IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4 kDa protein consisting of 121 amino acid residues.

      Sequence

      SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S


         

      性质

      recombinant  expressed in E. coli
      assay  ≥98% (HPLC)
       ≥98% (SDS-PAGE)
      form  lyophilized
      mol wt  mol wt 12.4 kDa
      impurities  <0.1 EU/μg endotoxin, tested
      suitability  cell culture tested
      UniProt accession no.  Q14005
      shipped in  wet ice
      storage temp.  ?20°C
      Gene Information  human ... IL16(3603)
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