别名:   Acrogranin Granulin-1 Paragranulin

产品名称

General description

Progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6.0 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88.0 kDa. The Progranulin is purified by standard chromatographic techniques.

Physical form

Sterile filtered clear solution in PBS

性质

recombinant	expressed in HEK 293 cells
assay	≥90% (HPLC)
	≥90% (SDS-PAGE)
form	liquid
mol wt	mol wt 88.0 kDa
concentration	0.5 mg/mL
impurities	Endotoxin, tested
NCBI accession no.	P28799
shipped in	wet ice
storage temp.	?20°C
Gene Information	human ... GRN(2896)