别名:   IGFBP-5

•  MDL number  MFCD04040883

• Popular Documents:  Datasheet (PDF)

产品名称

Analysis Note

The biological activity is measured by its ability to inhibit recombinant mouse IGF-II on MCF-7 cells.

Application

As a result of glycosylation, the recombinant mouse protein migrates to at least three bands with molecular weights ranging from 28-38 kDa in SDS-PAGE under reducing conditions.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Biochem/physiol Actions

IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.

IGFBPs (insulin-like growth factor binding proteins) control IGF functions by regulating their access to other proteins, including receptors. IGFBP5 is involved in osteogenesis, muscle differentiation and kidney development. It is a crucial protein for the development of fibrosis.

General description

IGFBP5 (insulin-like growth factor binding protein-5) is a secreted protein and can also move to the nucleus. IGFBPs have cysteine-rich amino- and carboxyl-terminal domains.

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