别名:   IGF-I Receptor

•  MDL number  MFCD01323726

• Popular Documents:  Datasheet (PDF)  |  Specification Sheet (PDF)

产品名称

Analysis Note

As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.

The biological activity is measured by its ability to bind human IGF­-­I in a functional ELISA assay.

Physical form

Lyophilized from a 0.2 μm solution in phosphate buffered saline.

Application

Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.

Biochem/physiol Actions

IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.

General description

IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.

性质