别名:   IFNA INFA2 Interferon α 2b

产品名称

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 1 mg/mL. This solution can then be diluted into other aqueous buffers.

Physical form

Lyophilized from 5 mM sodium phosphate, pH 7.4.

Application

IFN-α2b (interferon α 2b)-human has been used to study role of USP18 (ubiquitin specific peptidase 18)-mediation deISGylation in controlling cellular autophagy upon treatment with type I interferons.

Biochem/physiol Actions

IFN-α2b (interferon α 2b) is a lymphoid factor that possesses potent anti-viral activity. It mainly interacts with cell surface-specific receptors. This interaction is responsible for anti-pathogenic response in cells. IFN-α2b also exhibits anti-tumor activities. Humans with brain tumor were shown to have mutations in this gene.

General description

The gene IFN-α2b (interferon α 2b) is mapped to human chromosome 9. The encoded protein is a type 1 interferon and a glycoprotein. It belongs to the class of cytokines. Human IFN-α2b is a 19.3kDa protein containing 165 amino acid residues.

性质

recombinant	expressed in E. coli
assay	≥98% (HPLC)
	≥98% (SDS-PAGE)
form	lyophilized
mol wt	mol wt ~19.3 kDa
impurities	endotoxin, tested
NCBI accession no.	Q86UP4
shipped in	wet ice
storage temp.	?20°C
Gene Information	human ... IFNA2b(3440)