详细说明
Catalogue Number : 4804999
Description
Filipin III is the most prevalent isomer of the Filipin complex, a potent polyene macrolide antibiotic antifungal mixture. It is reported that it functions by disrupting the cell membrane. Filipin is also used as a histochemical stain for cholesterol as it is highly fluorescent to inhibit the raft/caveolae endocytosis pathway in mammalian cells.
Additional Information
Applications | FA |
Synonyms: | Filimirasin, Filmirisin |
Formulation: | Crystalline solid |
Chemical Name: | (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one |
Molecular Formula: | C35H58O11 |
Molecular Weight: | <div "class="productview-attribute-conten_div" style="margin: 0px; padding: 0px;">654.8 |
CAS Number
480-49-9
Purity:
≥85%
Storage Conditions:
Product should be kept at -20°C.
References:
Bittman, R., & Fischkoff, S. A. (1972). Fluorescence studies of the binding of the polyene antibiotics filipin III, amphotericin B, nystatin, lagosin to cholesterol. Proceedings of the National Academy of Sciences, 69(12), 3795-3799.
Pandey, R. G., & RINEHART, K. L. (1970). POLYENE ANTIBIOTICS. V. CHARACTERIZATION OF COMPONENTS OF THE FILIPIN COMPLEX BY MASS SPECTROMETRY 1). The Journal of antibiotics, 23(8), 414-417.
Orlandi, P. A., & Fishman, P. H. (1998). Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization activation through caveolae-like domains. The Journal of cell biology, 141(4), 905-915.
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