Catalogue Number : 1625605

Description

FTY720 is a sphingosine-1-phosphate receptor modulator that sequesters lymphocytes in lymph nodes, inhibiting their contribution to autoimmune responses. It is derived from myriocin (ISP-1), a fungal metabolite. FTY720 is also reported to be a cPLA2 inhibitor, a ceramide synthase inhibitor,  a cannabinoid receptor antagonist.

Additional Information

CAS Number

162359-56-0

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., ... & Lynch, K. R. (2002). The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Journal of Biological Chemistry, 277(24), 21453-21457.

Gräler, M. H., & Goetzl, E. J. (2004). The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. The FASEB journal, 18(3), 551-553.

Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., & Hoshino, Y. (1998). FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. The Journal of Immunology, 160(10), 5037-5044.