Catalogue Number : 8819813

Description

G-1 is a selective  potent agonist against the GPR30 receptor, an estradiol binding receptor that contributes to both uterine  neurological responses. G-1 inhibits the production of lipopolysaccharide (LPS) induced cytokines such as IL-6  TNF-alpha. It is also reported to block MCF-1 cell cycle progression at the G1 phase  display therapeutic effects in multiple sclerosis models.

Additional Information

CAS Number

881639-98-1

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Bologa, C. G., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., ... & Prossnitz, E. R. (2006). Virtual  biomolecular screening converge on a selective agonist for GPR30. Nature chemical biology,2(4), 207-212.

Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks-Miller, M., Mahmoudi, M., ... & Horuk, R. (2009). Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. Journal of neuroimmunology, 214(1), 67-77.

Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I., & Salehi, A. (2011). Insulinotropic  antidiabetic effects of 17β-estradiol  the GPR30 agonist G-1 on human pancreatic islets. Endocrinology, 152(7), 2568-2579.