详细说明
Catalogue Number : 6800637
Description
Tamoxifen is a modulator of the of the estrogen receptor, with tissue specific agonistic and antagonistic effects. (Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite with increased potency and a 100x higher affinity for the estrogen receptors. It is also reported to inhibit lipid peroxidation and can be used to activate intein-linked or estrogen receptor ERT2 domain fused Cas9 to reduce off target effects in CRISPR-mediated gene editing.
Additional Information
Applications | FA |
Synonyms: | 4OH-tamoxifen, (Z)-4-hydroxy Tamoxifen, Afimoxifene, OHTAM |
Formulation: | Crystalline solid |
Chemical Name: | 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol |
Molecular Formula: | C26H29NO2 |
Molecular Weight: | <div "class="productview-attribute-conten_div">387.5 |
CAS Number | 68047-06-3 |
Purity: | 鈮?8% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Smith, C. L., Nawaz, Z., & O鈥橫alley, B. W. (1997). Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Molecular endocrinology, 11(6), 657-666. Coward, P., Lee, D., Hull, M. V., & Lehmann, J. M. (2001). 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor 纬.Proceedings of the National Academy of Sciences, 98(15), 8880-8884. Vartak, S. V., & Raghavan, S. C. (2015). Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing. FEBS journal, 282(22), 4289-4294. |
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