详细说明
Catalogue Number : 2144674
Description
25-hydroxy Cholesterol is a dietary cholesterol derivative with a side chain substituted oxysterol that is capable of triggering the activation of many cholesterol molecules. It has been reported to activate ABCA1 signaling, atherosclerosis modulation, induces apoptosis in human cell lines through caspases activation bcl-2 downregulation. 25-hydroxy Cholesterol is immunomodulating is capable of suppressing macrophage differentiation from monocytes.
Additional Information
Applications | FA |
Synonyms: | 25-hydroxycholesterol, (3beta)-isomer, 5-cholestene-3beta,25-diol |
Formulation: | Crystalline solid |
Chemical Name: | (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
Molecular Formula: | C27H46O2 |
Molecular Weight: | <div "class="productview-attribute-conten_div" style="margin: 0px; padding: 0px;">402.7 |
CAS Number
2140-46-7
Purity:
≥98%
Storage Conditions:
Product should be kept at-20°C.
References:
Peng, S. K., Taylor, C. B., Hill, J. C., & Morin, R. J. (1985). Cholesterol oxidation derivatives arterial endothelial damage. Atherosclerosis, 54(2), 121-133.
Erickson, S. K., Matsui, S. M., Shrewsbury, M. A., Cooper, A. D., & Gould, R. G. (1978). Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, in hepatocytes. Journal of Biological Chemistry, 253(12), 4159-4164.
Aupeix, K., Weltin, D., Mejia, J. E., Christ, M., Marchal, J., Freyssinet, J. M., & Bischoff, P. (1995). Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiology, 194(4), 415-428.
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