生物来源

human

重组

expressed in E. coli

测定

≥98% (HPLC)
≥98% (SDS-PAGE)

形式

lyophilized

分子量

17.3 kDa

包装

pkg of 10 μg

杂质

<0.1 EU/μg endotoxin, tested

颜色

white to off-white

UniProt登记号

Q9NZH8

运输

wet ice

储存温度

−20°C

Gene Information

human ... IL36G(56300)

相关类别

Growth Factors and Cytokines

一般描述

IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3.

生化/生理作用

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.