产品编号:

AF-200-33

别名:

Interleukin-33, IL-1 F11, NF-HEV

描述:

Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family.  It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases.  IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues. Manufactured using all Animal-Free reagents.

氨基酸序列:

SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET

来源:

E.coli

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED₅₀ is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.

交叉反应:

Mouse, Human

原产国:

USA