同义词：   5-Cyano-N-(2,5-di(piperidin-1-yl)phenyl)furan-2-carboxamide  

应用；   A cell-permeable furan carboxamide compound  

CAS号码:   959626-45-0  

分子量:   378.47  

分子式:   C₂₂H₂₆N₄O₂  

* Refer to Certificate of Analysis for lot specific data (including water content).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

cFMS Receptor Inhibitor IV is a cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive c-Fms-CSF-1R (cFMS/CSF-1R) inhibitor. cFMS Receptor Inhibitor IV blocks cFMS autophosphorylation in cell-free in vitro kinase assays and in CSF-1/M-CSF-stimulated HEK-293 cells.

参考文献

1. Patch, Raymond J., et al., 2007. Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents. Bioorganic & medicinal chemistry letters. 17(22): 6070-4. PMID: 17904845

物理状态 :

Solid

溶解度 :

Soluble in DMSO (5 mg/ml).

保存 :

Store at -20° C

沸点 :

530.49° C at 760 mmHg (Predicted)

密度 :

1.26 g/cm    ³ (Predicted)

折射率 :

n    ²⁰    _D 1.63 (Predicted)

IC50 :

cFMS autophosphorylation: IC    ₅₀ = 17 nM (cell-free in vitro kinase assays); cFMS autophosphorylation: IC    ₅₀ = 76 nM (CSF-1/M-CSF-stimulated HEK-293 cells )

pK值 :

pK    _a: 10.55 (Predicted), pK    _b: 8.02 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.  

PubChem CID :

28408236

MDL 号码 :

MFCD10568148

SMILES :

C1CCN(CC1)C2=CC(=C(C=C2)N3CCCCC3)NC(=O)C4=CC=C(O4)C#N