应用；   A mixed sodium and calcium channel protein inhibitor  

CAS号码:   202825-45-4  

分子量:   398.45  

分子式:   C₁₈H₂₃FN₂O₅S.CH₃SO₃H  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. Inhibiton is voltage-dependent, with higher potency against inactivated channels. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents.

物理状态 :

Solid

溶解度 :

Soluble in water (25 mM), and DMSO (100 mM).

保存 :

Desiccate at 4° C

熔点 :

238-239° C

光学活性 :

α20/D 12.5°±2.5°, c = 1 in HOAc

IC50 :

Sodium channel protein type 1 subunit alpha: IC    ₅₀ = 8.2 µM; Sigma non-opioid intracellular receptor 1: IC    ₅₀ = 0.02 µM

仅供科研使用。不可用于诊断或治疗。  

PubChem CID :

3038502

SMILES :

C[C@@H](C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F.CS(=O)(=O)O