同义词：   (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione thiazolidine-2,4-dione, 4a; SMI-4a  

应用；   A selective and ATP-competitive Pim kinase inhibitor  

CAS号码:   438190-29-5  

纯度:   >98%  

分子量:   273.23  

分子式:   C₁₁H₆F₃NO₂S  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC₅₀ values = 24 and 100 nM for Pim-1 and Pim-2, respectively). TCS PIM-1 4a has been shown to display selectivity over a panel of approximately 50 other kinases tested. This compound also exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro. TCS PIM-1 4a is an inhibitor of Aldose Reductase and Cox-2.

参考文献

Xia et al (2009) Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J.Med.Chem. 52 74.

外观 :

Powder

物理状态 :

Solid

溶解度 :

Soluble in DMSO (55 mg/ml at 25 °C), ethanol (32 mg/ml at 25 °C), and water (slightly at 25 °C).

保存 :

Desiccate at 4° C

密度 :

~1.53 g/cm    ³ (Predicted)

折射率 :

n    ²⁰    _D ~1.60 (Predicted)

IC50 :

Pim-1: IC    ₅₀ = 24 nM (human); Pim-2: IC    ₅₀ = 0.1 µM (human); PC-3: IC    ₅₀ = 17 µM (human); DLD-1: IC    ₅₀ = 17.8 µM (human); HT-29: IC    ₅₀ = 31.4 µM (human)

Ki 数据 :

Pim-1: K    _i= 24 nM (human); Pim-2: K    _i= 0.1 µM (human)

pK值 :

pK    _a: 7.38 (Predicted)

仅供科研使用。不可用于诊断或治疗。  

德国水公害等级 :

3

PubChem CID :

1361334

MDL 号码 :

MFCD01152003

SMILES :

C1=CC(=CC(=C1)C(F)(F)F)/C=C\2/C(=O)NC(=O)S2