同义词：   N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide  

应用；   An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1  

CAS号码:   300586-90-7  

分子量:   237.26  

分子式:   C₁₄H₁₁N₃O  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

OAC-1 is an Oct-4 activator which enhances and accelerates iPSC reprogramming in the presence of 4F (Oct-4, Sox-2, c-Myc and GKLF) by ~20-fold (relative to 4F by itself). OAC-1 upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1. It has shown no effects, however, on the p53-p21 pathway or Wnt-β-catenin signaling.

参考文献

1. Li, Wendong., et al., 2012. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences of the United States of America. 109(51): 20853-8. PMID: 23213213

物理状态 :

Solid

保存 :

Store at -20° C

熔点 :

197.05° C (Predicted)

沸点 :

~386.6° C at 760 mmHg (Predicted)

密度 :

~1.4 g/cm    ³ (Predicted)

折射率 :

n    ²⁰    _D 1.76 (Predicted)

仅供科研使用。不可用于诊断或治疗。  

PubChem CID :

789882

SMILES :

C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3