同义词：   Eicosapentaenoic Acid; Icosapent  

应用；   A 5-LO inhibitor  

CAS号码:   10417-94-4  

纯度:   ≥98%  

分子量:   302.45  

分子式:   C₂₀H₃₀O₂  

Supplemental Information:   This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) (EPA), an ω-3 fatty acid, has been reported to act as a precursor to thromboxanes and prostaglandins (PG). EPA inhibits amino acid oxygenation by PG endoperoxide H synthase-1 and 5-LO (5-lipoxygenase). Experiments have demonstrated the ability of EPA to increase Cafestol palmitate (sc-205613) incorporation into the lipid fraction and decrease the rate of fatty acid oxidation in murine adipose tissue. Additionally, this agent has demonstrated the ability to cause a decrease in gene expression for IL-6 and TNF-α both in skeletal muscle and adipose tissue.

参考文献

1. Yerram, N.R., et al. 1989. J. Lipid Res. 30: 1747-1757. PMID: 2559136
2. Roth, H.P. and Kirchgessner, M. 1992. Ann. Nutr. Metab. 36: 113-120. PMID: 1354951
3. Wada, M., et al. 2007. J. Biol. Chem. 282: 22254-22266. PMID: 17519235
4. Figueras, M., et al. 2010. Obesity. [Epub ahead of print]. PMID: 20885391

外观 :

Oil

物理状态 :

Liquid

溶解度 :

Soluble in ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), chloroform, ethyl acetate, and methanol.

保存 :

Store at -20° C

熔点 :

-54--53° C

沸点 :

439.30° C at 760 mmHg

密度 :

0.94 g/mL at 25° C (lit.)

折射率 :

n    ²⁰    _D 1.50 (lit.)

IC50 :

mPGES1: IC    ₅₀ = 300 nM; Cyclooxygenase-2: IC    ₅₀ = 7100 nM (Ovis aries)

pK值 :

pK    _a: 4.75

仅供科研使用。不可用于诊断或治疗。  

德国水公害等级 :

3

RTECS :

JX3820000

运输 :

UN 3265, Class 8, Packing group III

PubChem CID :

446284

默克索引 :

14: 3531

MDL 号码 :

MFCD00065716

EC号码 :

600-528-7

Beilstein 注册 :

1714433

SMILES :

CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O