同义词：   3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone  

应用；   A mitochondrial complex II inhibitor able to protect against cardiac-reperfusion  

CAS号码:   119509-24-9  

纯度:   ≥95%  

分子量:   366.2  

分子式:   C₁₅H₂₁Cl₂NO₅  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

Atpenin A5 belongs to a class of antifungal antibiotics isolated from Penicillium sp. The atpenins are effective against filamentous fungi, particularly Trichophyton sp., and are specific and potent inhibitors of the succinate-ubiquinone reducatase activity of the mitochondrial complex II. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels. Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD.

参考文献

1. Omura, S., et al. 1988. J. Antibiot. 41: 1769-1773. PMID: 3209470
2. Kumagai, H., et al. 1990. J. Antibiot. 43: 1553-1558. PMID: 2276974
3. Miyadera, H., et al. 2003. Proc. Natl. Acad. Sci. U.S.A. 100: 473-477. PMID: 12515859
4. Wojtovich, A.P., et al. 2009. Basic Res. Cardiol. 104: 121-129. PMID: 19242645
5. Ohtawa, M., et al. 2009. J. Antibiot. 62: 289-294. PMID: 19373276

外观 :

Powder

物理状态 :

Solid

来源于 :

Synthetic, originally isolated from     Penicillium sp strain FO-125

溶解度 :

Soluble in acetone, acetonitrile, chloroform, ethyl acetate, DMSO, methanol, and 100% ethanol. Insoluble in water, and hexane.

保存 :

Store at -20° C

熔点 :

83-86° C

沸点 :

532.59° C at 760 mmHg (Predicted)

密度 :

1.31 g/cm    ³  

折射率 :

n    ²⁰    _D 1.53 (Predicted)

IC50 :

bovine heart complex II: IC    ₅₀ = 3.6 nM; fumarate reductase: IC    ₅₀ = 12 nM (Ascaris suum); E. coli succinate dehydrogenase: IC    ₅₀ = 5 µM

pK值 :

pK    _a: 4.5, pK    _b: 0.98

仅供科研使用。不可用于诊断或治疗。  

RTECS :

CJ8800000

PubChem CID :

197273

SMILES :

C[C@@H](C[C@H](C)C(=O)C1=C(NC(=C(C1=O)OC)OC)O)[C@H](CCl)Cl