同义词：   1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid, 4-Methoxyphenyl Ester  

应用；   A potent and selective inhibitor of COX-2  

CAS号码:   261766-24-9  

分子量:   463.91  

分子式:   C₂₆H₂₂ClNO₅  

* Refer to Certificate of Analysis for lot specific data (including water content).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

Indomethacin Ester, 4-Methoxyphenyl- is a cell-permeable 4-methoxyphenyl ester derivative of the non-steroidal anti-inflammatory drug (NSAID). It is a potent and selective inhibitor of COX-2 compared to COX-1.

参考文献

1. Kalgutkar, A S., et al., 2000. Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 97(2): 925-30. PMID: 10639181
2. Kalgutkar, A S., et al., 2000. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. Journal of medicinal chemistry. 43(15): 2860-70. PMID: 10956194

物理状态 :

Solid

溶解度 :

Soluble in DMSO (100 mg/ml), and warm methanol (2.5 mg/ml).

保存 :

Store at -20° C

熔点 :

248.87° C (Predicted)

沸点 :

583.20° C at 760 mmHg (Predicted)

密度 :

1.26 g/cm    ³ (Predicted)

折射率 :

n    ²⁰    _D 1.6 (Predicted)

IC50 :

COX-2: IC    ₅₀ = 40 nM; COX-1: IC    ₅₀ = > 66 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.  

PubChem CID :

10766544

MDL 号码 :

MFCD03452681

SMILES :

CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OC4=CC=C(C=C4)OC