同义词：   Givinostat  

应用；   A potent inhibitor of HDAC with IC₅₀ of 7.5-16 nM  

CAS号码:   732302-99-7  

分子量:   475.97  

分子式:   C₂₄H₂₇N₃O₄.HCl.H₂O  

* Refer to Certificate of Analysis for lot specific data (including water content).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

TF2357 (Givinostat) is a potent inhibitor of HDAC with IC₅₀ of 7.5-16 nM. ITF2357 reduces the release of TNFα, IL-1α, IL-1β, and IFNγ, in PBMCs with IC₅₀ of 10-25 nM, respectively. ITF2357 activates the intrinsic apoptotic pathway, up-regulates p21 and down-regulates Bcl-2 and Mcl-1. ITF2357 inhibits the production of IL-6, VEGF, and IFNγ in mesenchymal stromal cells (MSCs) by 80-95%. ITF2357 favors β-cell survival during inflammatory conditions. ITF2357 at concentrations of 25 and 250 nM increases islet cell viability, enhances insulin secretion, inhibits release of MIP-1α and MIP-2, reduces NO production and decreases apoptosis rates.

保存 :

Store at -20° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.  

PubChem CID :

9804991

SMILES :

CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl