同义词：   Camptosar; Campto; CPT-11  

应用；   An inhibitor of Topo I  

CAS号码:   136572-09-3  

纯度:   ≥99%  

分子量:   677.1  

分子式:   C₃₃H₃₈N₄O₆•HCl•₃H₂O  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

Irinotecan hydrochloride trihydrate, Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite, SN 38 (sc-203697) and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecan's active metabolite SN 38 is additionally noted to activate p53 in the Huh7 cell line.

参考文献

1. Goto, S., et al. 1996. Anticancer Res. 16: 2507-2511. PMID: 8917343
2. Worden, F.P. et al. 2000. Expert Opin Investig Drugs. 9: 565-579. PMID: 11060696
3. Kellner, U., et al. 2000. Onkologie. 23: 424-430. PMID: 11441236
4. Takeba, Y., et al. 2007. J. Pharmacol. Sci. 104: 232-242. PMID: 17609585

物理状态 :

Solid

溶解度 :

Soluble in water, and methanol.

保存 :

Store at 4° C

熔点 :

250-256° C

沸点 :

873.4° C at 760 mmHg (Predicted)

仅供科研使用。不可用于诊断或治疗。  

PubChem CID :

22727521

SMILES :

CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl