分子量:   331.5  

分子式:   C₂₀H₂₁D₁₁O₃  

* Refer to Certificate of Analysis for lot specific data (including water content).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

Contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18' ,19, 19' ,20, 20, and 20 positions. Intended for use as an internal standard for the quantification of (±)14(15)-EET by GC- or LC-MS. (±)14,15-DiHETrE is biosynthesized in rat and rabbit liver microsomes by CYP450. Dramatic increases in urinary (±)14,15-DiHETrE, a (±)14(15)-EET metabolite, have been documented by GC/MS in pregnancy induced hypertension.

参考文献

Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982). 2 Oliw, E.H., Guengerich, F.P., Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982). 3 Catella, F., Lawson, J.A., Fitzgerald, D.J., et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proc Natl Acad Sci USA 87 5893-5897 (1990).

规划 :

A solution in ethanol

物理状态 :

Liquid

保存 :

Store at -20° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.