应用；   A differentiation inducer and HDAC inhibitor prodrug  

纯度:   ≥95%  

分子量:   476.7  

分子式:   C₃₁H₄₀O₄  

* Refer to Certificate of Analysis for lot specific data (including water content).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

ATRA-BA Hybrid is the combination of a differentiation-inducer all-trans-Retinoic Acid and the HDAC inhibitor Butyric Acid that have been incorporated chemically via a benzyl ester linkage into a single more permeant mutual prodrug (MP) to help their cellular uptake and to better synergize their cancer killing efficiency.

参考文献

Gediya, L.K., et al. 2008. J. Med. Chem. 51, 3895.
R: 22-36/37/38-63; S: 22-26-36-45

物理状态 :

Solid

溶解度 :

Soluble in DMSO (5 mg/ml), and ethanol.

保存 :

Store at -20° C

沸点 :

597.04° C at 760 mmHg (Predicted)

密度 :

1.05 g/cm    ³ (Predicted)

折射率 :

n    ²⁰    _D 1.55 (Predicted)

IC50 :

PC-3: IC    ₅₀ = 1.02 µM; MDA-MB-231 : IC    ₅₀ = 0.01 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.  

PubChem CID :

24894414

MDL 号码 :

MFCD11856059

SMILES :

CCCC(=O)OCC1=CC=C(C=C1)OC(=O)C=C(C)C=CC=C(C)C=CC2=C(CCCC2(C)C)C